Three Powders and a Purr: How I Calmed My Anxious Cat (Without a Prescription)

Here’s the Scoop:

• Why prescription meds weren’t a match for our meltdown-prone boy

• The three calming supplements I give Lars daily (with links and science!)

• Real progress we’ve seen with his separation anxiety and noise sensitivity

• A hopeful word if your cat currently thinks your absence is a national emergency

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If you’ve been around here a while, or read my previous post about Lars and his glorious emotional baggage, you know that this sweet boy has separation anxiety with a capital S-A.

At home? He’s a dream. A slightly dramatic dream, but a dream nonetheless. He plays, purrs, eats well, snuggles like a pro and patrols the hallway like he’s got rent to pay. But the moment we leave for an overnight trip? Cue the panic burrow, hunger strike and full-on kitty ghost mode.

We once had to come home early from a trip because he refused to eat or drink the entire time we were gone. That’s when I knew we needed to find a better solution...not just for us, but for his little heart.

I tried fluoxetine (kitty Prozac), but honestly? It felt like using a leaf blower to fluff a throw pillow. Just way too strong for something that’s not a daily issue. So I started experimenting with supplements. Nothing sedating. Nothing intense. Just gentle, natural support to help him feel safer and more at ease. And I’m happy to report, we’ve made huge progress.

Lars still hides during the day when we’re away, but now he comes out at night, eats, drinks and uses the litter box...which, for us, is basically cat-parent Mardi Gras.

The Trio of Supplements That Made All The Difference

1. Purina Calming Care Probiotic

This one’s a daily must in our house. It’s not just any probiotic, it features a specific strain called Bifidobacterium longum that’s actually been studied for its calming effects.

Here’s how it works:

• This strain communicates with the gut-brain axis (yes, cats have one too!) to help regulate stress responses.

• It promotes the production of calming neurotransmitters in the brain.

• Basically, it helps take the edge off by reducing reactivity to everyday stressors.

Since starting this, Lars has been way less jumpy when the garbage truck drives by or someone drops a fork in the kitchen. And the best part? It’s gentle enough for daily use and great for his gut, too.

2. Zylkene (Vetoquinol)

Zylkene is made from alpha-casozepine, a compound derived from milk protein that mimics the calming peptides found in a mother cat’s milk. (I know. Cue the heart clutch.)

Here’s why it works:

• It binds to GABA-A receptors, which are part of the brain’s chill-out system.

• Think of it as nature’s way of whispering, “You’re okay. You’re safe. You’ve got this.”

It doesn’t sedate, but it takes the emotional volume knob down a few notches. I give it to Lars daily in his food and I swear he struts through the house like he just got back from a yoga retreat.

3. Fera Pet Organics Calming Support Powder

I tried giving Lars just L-theanine by itself, but it didn’t do much. This blend, though? Amazingness.

It includes:

• L-theanine (promotes alpha brain waves = calm focus)

• GABA (helps reduce nervous energy)

• Ashwagandha (a stress adaptogen)

• Tryptophan (precursor to serotonin = happy vibes)

• Valerian Root & Chamomile (nature’s bedtime tea in a bowl)

It’s a powder that mixes into his food seamlessly and the combo of ingredients seems to work better than any single one on its own.

The Result?

Lars still isn’t throwing parties when we’re gone, but he’s made major strides:

• He now eats and drinks while we’re away (no more hunger strikes)

• He uses the litter box consistently (not a given when he’s anxious)

• He comes out at night for several hours instead of staying hidden 24/7

• He’s less startled by household noises even when we’re home

I’d still love for him to feel totally chill all day while we’re gone, but honestly? I’m so proud of how far he’s come and these supplements are absolutely part of that progress.

If your cat is going through something similar, you’re not alone...and you’re not stuck. The right mix of natural support, time and TLC can make a world of difference.

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Takeaway Treats:

• Fluoxetine felt too strong for Lars’ situational anxiety...supplements were a better fit.

• Purina Calming Care uses a specific probiotic strain (BL999) to calm the brain via the gut.

• Zylkene mimics calming milk peptides to soothe your cat’s nervous system.

• Fera Calming Powder combines multiple gentle ingredients for all-day support.

• After several months on this trio, Lars is eating, drinking and coping much better while we’re away.